1. A na-atụ anya na ọ ga-emeziwanye ohere nke ọdịda akụrụ na ọnwụ site na ọrịa akụrụ
Otu ọdịnaya nke WuXi AppTec Medical New Vision weputara ozi na nyocha nke mmadụ 10,000 gosiri na metformin nwere ike imeziwanye ohere nke ọdịda akụrụ na ọnwụ site na ọrịa akụrụ.
Otu nnyocha e bipụtara na American Diabetes Association (ADA) journal "Diabetes Care" (Diabetes Care) gosiri na ọgwụ na nlanarị nyocha nke ihe karịrị mmadụ 10,000 gosiri na ụdị 2 ọrịa shuga mellitus na-arịa ọrịa akụrụ na-adịghị ala ala (CKD) na-ewere Metformin. Mbelata ihe ize ndụ nke ọnwụ na ọrịa gbasara akụrụ ọgwụgwụ (ESRD), ọ naghị abawanye ohere nke lactic acidosis.
Ọrịa akụrụ na-adịghị ala ala bụ ihe na-akpatakarị ọrịa shuga.N'iburu n'uche na enwere ike ịnye ndị ọrịa nwere ọrịa akụrụ dị nro metformin, ndị otu nyocha nyochara ndị ọrịa 2704 n'ime otu abụọ ahụ na-ewere metformin na-ewereghị metformin.
Nsonaazụ gosiri na ma e jiri ya tụnyere ndị na-ewereghị metformin, ndị ọrịa were metformin nwere mbelata 35% n'ihe ize ndụ nke ọnwụ na-akpata ọnwụ yana mbelata 33% n'ihe ize ndụ nke ịga n'ihu na ọrịa akụrụ na njedebe.Uru ndị a pụtara nke nta nke nta mgbe ihe dị ka afọ 2.5 were metformin.
Dị ka akụkọ ahụ si kwuo, n'ime afọ ndị na-adịbeghị anya, ntuziaka US FDA na-atụ aro izu ike iji metformin na ndị ọrịa nwere ụdị ọrịa shuga 2 nwere ọrịa akụrụ na-adịghị ala ala, mana ọ bụ naanị na ndị ọrịa nwere ọrịa akụrụ dị nro.Maka ndị ọrịa nwere oke oke (ọkwa 3B) yana ọrịa akụrụ na-adịghị ala ala, ojiji metformin ka na-arụ ụka.
Dr. Katherine R. Tuttle, bụ́ prọfesọ na Mahadum Washington dị na United States, kwuru, sị: “Ihe si ná nnyocha ahụ pụta na-emesi obi ike.Ọbụlagodi na ndị ọrịa nwere nnukwu ọrịa akụrụ, ihe ize ndụ nke lactic acidosis dị obere.Maka ndị ọrịa nwere ụdị ọrịa shuga 2 na ọrịa akụrụ na-adịghị ala ala, metformin nwere ike ịbụ ihe mgbochi ọnwụ yana ọgwụ dị mkpa maka ọdịda akụrụ, mana ebe nke a bụ nyochaghachi azụ na nyocha, a ga-eji nlezianya kọwaa nsonaazụ ya. ”
2. Ike ọgwụgwọ dị iche iche nke ọgwụ anwansi metformin
Enwere ike ikwu na Metformin bụ ọgwụ ochie ochie nke dịruworo ogologo oge.Na mmụba nke nyocha ọgwụ hypoglycemic, na 1957, ọkà mmụta sayensị France bụ́ Stern bipụtara nsonaazụ nyocha ya wee tinye mgbakwunye lilac nke nwere ọrụ hypoglycemic na agwa ewu.Alkali, aha ya bụ metformin, Glucophage, nke pụtara onye na-eri shuga.
N'afọ 1994, FDA kwadoro metformin maka ojiji na ụdị ọrịa shuga 2.Metformin, dị ka ọgwụ ikike maka ọgwụgwọ nke ụdị ọrịa shuga 2, edepụtara dị ka ọgwụ hypoglycemic nke izizi n'ọtụtụ ntuziaka ọgwụgwọ n'ụlọ na mba ọzọ.Ọ nwere uru nke mmetụta hypoglycemic ziri ezi, obere ihe ize ndụ nke hypoglycemia na ọnụ ala dị ala.Ugbu a ọ bụ ọgwụ a na-ejikarị eme ihe Otu n'ime klaasị ọgwụ hypoglycemic.
Dị ka ọgwụ a nwalere oge, a na-eme atụmatụ na e nwere ihe karịrị nde 120 ndị na-eji metformin eme ihe n'ụwa nile.
Site na nyocha miri emi nke nyocha, ike ọgwụgwọ nke metformin ka na-agbasawanye.Na mgbakwunye na nchọpụta ọhụrụ, a chọpụtakwara metformin nwere ihe fọrọ nke nta ka ọ bụrụ 20 mmetụta.
1. Mgbochi ịka nká mmetụta
Ka ọ dị ugbu a, US Food and Drug Administration akwadola nnwale ụlọ ọgwụ nke "iji metformin na-alụ ọgụ ịka nká".Ihe kpatara ndị ọkà mmụta sayensị si mba ọzọ ji metformin dị ka onye na-achọ ọgwụ mgbochi ịka nká nwere ike ịbụ n'ihi na metformin nwere ike ịbawanye ọnụ ọgụgụ nke mkpụrụ ndụ oxygen na-ahapụ n'ime sel.Karịsịa, nke a yiri ka ọ na-eme ka ahụ dịkwuo mma ma na-agbatị ndụ.
2. Mbelata ibu
Metformin bụ ọgwụ hypoglycemic nke nwere ike felata.Ọ nwere ike ịbawanye mmetụta insulin ma belata njikọ abụba.Maka ọtụtụ ndị hụrụ shuga n'anya ụdị shuga 2, mbelata ibu n'onwe ya bụ ihe na-enyere aka ịchịkwa shuga ọbara kwụsie ike.
Otu nnyocha nke otu United States Prevention Programme Prevention Programme (DPP) gosiri na n'ime afọ 7-8 na-enweghị ìsì, ndị ọrịa natara ọgwụgwọ metformin tụfuru ihe dị ka kilogram 3.1 n'ịdị arọ.
3. Belata ihe ize ndụ nke ime ọpụpụ na ịmụ nwa oge maka ụfọdụ ụmụ nwanyị dị ime
Nnyocha ọhụrụ e bipụtara na Lancet gosiri na metformin nwere ike ibelata ohere ime ime na ịmụ nwa na ụfọdụ ụmụ nwanyị dị ime.
Dị ka akụkọ si kwuo, ndị ọkà mmụta sayensị si Norwegian University of Science and Technology (NTNU) na St. Olavs Hospital mere nnyocha ihe fọrọ nke nta ka ọ bụrụ afọ 20 ma chọpụta na ndị ọrịa nwere polycystic ovary syndrome na-ewere metformin na njedebe nke ọnwa 3 nke ime ime nwere ike ibelata post- oge ime ọpụpụ na ime ọpụpụ.Ihe ize ndụ nke ịmụ nwa.
4. Gbochie mbufụt nke anwụrụ ọkụ kpatara
Nsonaazụ nke ọmụmụ ahụ gosiri na ndị otu Prọfesọ Scott Budinger nke Mahadum Northwwest duziri na ụmụ oke na metformin nwere ike igbochi mbufụt nke smog na-akpata, gbochie mkpụrụ ndụ ndị na-alụso ọrịa ọgụ ịhapụ ụmụ irighiri ihe dị ize ndụ n'ime ọbara, gbochie nguzobe nke thrombosis akwara, wee si otú ahụ gbochie. belata usoro obi.Ihe ize ndụ nke ọrịa.
5. Nchekwa obi
Metformin nwere mmetụta nchebe obi yana ugbu a bụ naanị ọgwụ hypoglycemic nke ntuziaka ọrịa shuga na-atụ aro ka ọ nwere ihe akaebe doro anya nke uru obi.Nnyocha e mere egosiwo na ọgwụgwọ ogologo oge nke metformin nwere njikọ chiri anya na mbelata nke ọrịa obi na ndị ọrịa nwere ụdị ọrịa shuga 2 nke achọpụtara ọhụrụ na ndị ọrịa nwere ọrịa shuga 2 bụ ndị butere ọrịa obi.
6. Mma polycystic ovary syndrome
Polycystic ovary syndrome bụ ọrịa dị iche iche nke a na-eji hyperandrogenemia, dysfunction ovary, na polycystic ovary morphology mara.Achọpụtaghị ihe kpatara ya, yana ndị ọrịa na-enwekarị ogo hyperinsulinemia dị iche iche.Nnyocha egosiwo na metformin nwere ike ibelata nguzogide insulin, weghachi ọrụ ovulation ya, ma melite hyperandrogenemia.
7. Meziwanye ihe ọkụkụ nke eriri afọ
Nnyocha e mere egosiwo na metformin nwere ike iweghachi oke nke osisi intestinal ma mee ka ọ gbanwee n'ụzọ dị mma maka ahụike.Ọ na-enye ebe obibi dị mma maka nje bacteria bara uru na eriri afọ, si otú ahụ na-ebelata shuga ọbara ma na-achịkwa usoro ahụ ji alụso ọrịa ọgụ nke ọma.
8. A na-atụ anya na ọ ga-agwọ ụfọdụ autism
N'oge na-adịbeghị anya, ndị na-eme nchọpụta na Mahadum McGill chọpụtara na metformin nwere ike ịgwọ ụdị ụfọdụ nke ọrịa Fragile X na autism, na e bipụtara nchọpụta ọhụrụ a n'akwụkwọ akụkọ Nature Medicine, nke sub- mbipụta nke Nature.Ka ọ dị ugbu a, Autism bụ otu n'ime ọtụtụ ọnọdụ ahụike ndị sayensị kwenyere na enwere ike iji metformin gwọọ ya.
9. Reverse pulmonary fibrosis
Ndị na-eme nchọpụta na Mahadum Alabama na Birmingham chọpụtara na n'ime ndị ọrịa na-arịa ọrịa idiopathic pulmonary fibrosis na ụdị fibrosis pulmonary fibrosis nke bleomycin kpatara, ọrụ AMPK na fibrotic na-ebelata, na anụ ahụ na-eguzogide mkpụrụ ndụ Apọptotic myofibroblasts mụbara.
Iji metformin mee ka AMPK rụọ ọrụ na myofibroblasts nwere ike ime ka mkpụrụ ndụ ndị a nwetaghachi apoptosis.Ọzọkwa, n'ụdị òké, metformin nwere ike mee ka mkpochapụ nke anụ ahụ fibrotic emepụtala ngwa ngwa.Ọmụmụ ihe a na-egosi na enwere ike iji metformin ma ọ bụ agonists AMPK ọzọ gbanwee fibrosis nke merelarị.
10. Nyere aka ịkwụsị ise siga
Ndị na-eme nchọpụta na Mahadum Pennsylvania achọpụtala na iji nicotine mee ihe ogologo oge nwere ike iduga n'ịgbalite ụzọ akara AMPK, nke a na-egbochi n'oge nkwụsị nicotine.Ya mere, ha kwubiri na ọ bụrụ na a na-eji ọgwụ eme ihe iji mee ka ụzọ mgbaàmà AMPK rụọ ọrụ, ọ nwere ike ibelata nzaghachi nkwụsị.
Metformin bụ agonist AMPK.Mgbe ndị ọrụ nyocha ahụ nyere metformin ụmụ oke nwere nicotine ndọpụ, ha chọpụtara na ọ na-ebelata mwepu ụmụ oke ahụ.Nnyocha ha gosiri na enwere ike iji metformin nyere aka ịkwụsị ise siga.
11. Mmetụta mgbochi mkpali
Na mbụ, nyocha izizi na ụlọ ọgwụ egosila na metformin nwere ike ọ bụghị naanị melite mbufụt na-adịghị ala ala site na ịkwalite usoro metabolic dị ka hyperglycemia, nguzogide insulin na atherosclerotic dyslipidemia, kamakwa ọ nwere mmetụta mgbochi mkpali.
Nnyocha egosiwo na metformin nwere ike igbochi mbufụt, tumadi site na AMP-activated protein kinase (AMPK) -dabere ma ọ bụ mgbochi nnwere onwe nke ihe ngbanwe nke nuklia B (NFB).
12. Weghachite ihe nhụsianya
Ndị na-eme nchọpụta na Mahadum Texas dị na Dallas emepụtala ụdị òké nke na-eṅomi mmekpa ahụ metụtara mgbu.Ha jiri ihe nlereanya a nwalee ịdị irè nke ọtụtụ ọgwụ.
Nsonaazụ nnwale na-egosi na ọgwụgwọ ụmụ oke nwere 200 mg/kg arọ ahụ nke metformin maka ụbọchị 7 nwere ike weghachi nhụsianya nghọta nke mgbu na-akpata.
Gabapentin, nke na-agwọ neuralgia na Akwụkwụ na-adọ, enweghị mmetụta dị otú ahụ.Nke a pụtara na enwere ike iji metformin dị ka ọgwụ ochie iji gwọọ nsogbu uche na ndị ọrịa nwere neuralgia.
13. Na-egbochi uto tumor
Ụbọchị ole na ole gara aga, dị ka Singularity.com si kwuo, ndị ọkà mmụta si European Institute of Oncology chọpụtara na metformin na ibu ọnụ nwere ike ịrụ ọrụ synergistically iji gbochie uto nke etuto òké.
Site na nyocha ọzọ, a chọpụtara na metformin na ibu ọnụ na-egbochi uto tumor site na ụzọ PP2A-GSK3β-MCL-1.E bipụtara nyocha ahụ na Cell Cancer.
14. Nwere ike igbochi macular degeneration
Dr. Yu-Yen Chen si Taichung Veterans General Hospital na Taiwan, China chọpụtara n'oge na-adịbeghị anya na nrịanrịa nke macular degeneration (AMD) metụtara afọ na ndị ọrịa nwere ụdị ọrịa shuga 2 na-ewere metformin dị obere.Nke a na-egosi na ka ị na-achịkwa ọrịa shuga, ọrụ mgbochi mkpali na antioxidant nke metformin nwere mmetụta nchebe na AMD.
15. Ma ọ bụ nwee ike ịgwọ ntutu isi
Ndị otu Huang Jing, onye ọkà mmụta sayensị China na Mahadum California, Los Angeles, chọpụtara na ọgwụ ndị dị ka metformin na rapamycin nwere ike ịkpalite ntutu isi n'oge ezumike nke oke iji banye n'oge uto ma kwalite uto ntutu.Ebipụtala nchọpụta metụtara ya na akwụkwọ akụkọ agụmakwụkwọ ama ama Cell Reports.
Ọzọkwa, mgbe ndị ọkà mmụta sayensị jiri metformin na-agwọ ndị ọrịa nwere polycystic ovary syndrome na China na India, ha achọpụtala na metformin jikọtara ya na mbelata ntutu isi.
16. Reverse ndu afọ
N'oge na-adịbeghị anya, ebe nrụọrụ weebụ gọọmentị nke akwụkwọ akụkọ sayensị na nkà na ụzụ mba ụwa "Nature" bipụtara akụkọ na-egbochi.Akụkọ na-egosi na obere nchọpụta ụlọ ọgwụ na California gosipụtara na nke mbụ na ọ ga-ekwe omume ịtụgharị elekere epigenetic mmadụ.N'afọ gara aga, ndị ọrụ afọ ofufo itoolu nwere ahụike were ngwakọta nke homonụ na-eto eto na ọgwụ shuga abụọ, gụnyere metformin.N'ịtụle site n'ịtụle ihe nrịbama na genome mmadụ, afọ ndụ ndụ ha agbadala nkezi nke afọ 2.5.
17. Ngwakọta ọgwụ nwere ike ịgwọ ọrịa kansa ara na-adịghị mma nke ugboro atọ
Ụbọchị ole na ole gara aga, otu Dr. Marsha Rich Rosner nke Mahadum Chicago duuru chọpụtara na ngwakọta nke metformin na ọgwụ ochie ọzọ, heme (panhematin), nwere ike ilekwasị anya n'ịgwọ ọrịa kansa ara na-adịghị mma nke ugboro atọ nke na-eyi ahụ ike ụmụ nwanyị egwu nke ukwuu. .
Ma enwere ihe akaebe na usoro ọgwụgwọ a nwere ike ịdị irè maka ọrịa cancer dị iche iche dị ka ọrịa kansa akpa ume, ọrịa akụrụ, ọrịa cancer uterine, ọrịa prostate na nnukwu ọrịa leukemia myeloid.Ebipụtala nyocha metụtara ya na akwụkwọ akụkọ kacha elu Nature.
18. Nwere ike ibelata mmetụta ọjọọ nke glucocorticoids
N'oge na-adịbeghị anya, "Lancet-Diabetes and Endocrinology" bipụtara ọmụmụ-nsonaazụ nke ọmụmụ ahụ gosiri na n'ime usoro nke abụọ nke ụlọ ọgwụ, metformin na-eji ndị ọrịa na-arịa ọrịa na-adịghị ala ala na-eme ka ahụike dịkwuo mma ma belata ọgwụgwọ glucocorticoid Mmetụta dị egwu.
Nnwale egosila na metformin nwere ike na-arụ ọrụ site na isi protein AMPK nke metabolic, na usoro a na-eme bụ ihe megidere glucocorticoids, ma nwee ike iweghachite nsonaazụ ndị sitere na iji glucocorticoids buru ibu.
19. Olileanya ịgwọ ọrịa sclerosis
Na mbụ, otu nyocha nke Robin JM Franklin nke Mahadum Cambridge na onye na-eso ụzọ ya bụ Peter van Wijngaarden bipụtara otu akụkọ n'akwụkwọ akụkọ kachasị elu "Cell Stem Cells" na ha chọtara ụdị pụrụ iche nke mkpụrụ ndụ akwara akwara nke nwere ike ịgbake mgbe a gwọchara ya. metformin.Na nzaghachi nye akara ngosi dị iche iche na-akwalite, ọ na-apụtaghachi ike ntorobịa ma na-akwalite nkwalite nke myelin irighiri akwara.
Nchọpụta a pụtara na a na-atụ anya na a ga-eji metformin mee ihe n'ịgwọ ọrịa ndị metụtara neurodegeneration na-adịghị agbanwe agbanwe, dị ka multiple sclerosis.
Oge nzipu: Eprel-21-2021